C34H40N4O7S
648.8 g/mol
Pharmaceutical IntermediateWarning
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid
CAS187618-60-6EC606-116-3
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
Fmoc-D-Arg(Pbf)-OH is a protected arginine derivative used in solid-phase peptide synthesis. It features a fluorenylmethoxycarbonyl (Fmoc) protecting group on the amino terminus and a 2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl (Pbf) group on the guanidine side chain, facilitating the construction of peptides with controlled stereochemistry.
Protected building block for peptide synthesisResearch reagent for solid-phase peptide synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 187618-60-6
Related Compounds
SimilarStructure SimilarSimilarity 0.83
N-Fmoc-N'-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl)-L-homearginine
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SimilarStructure SimilarSimilarity 0.79
Fmoc-Arg(Pbf)-Ser(Psi(Me,Me)pro)-OH
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Referencestereoisomer of
FMOC-Arg(Pbf)-OH
CAS154445-77-9
pharmaceutical intermediate
Safety Reference
Warning
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
Identifiers
IUPAC Name
(2R)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
InChIKey
HNICLNKVURBTKV-MUUNZHRXSA-N
SMILES
CC1=C(C(=C(C2=C1OC(C2)(C)C)C)S(=O)(=O)NC(=NCCC[C@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)N)C
Synonyms (18)
- Fmoc-D-Arg(Pbf)-OH
- Fmoc-D-Arg(pbf)
- Na-Fmoc-N?-Pbf-D-arginine