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Home/Compounds/Pharmaceutical Intermediate/FMOC-Arg(Pbf)-OH
C34H40N4O7S
648.8 g/mol
Pharmaceutical Intermediate

N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine

CAS154445-77-9
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate

Fmoc-Arg(Pbf)-OH is a protected arginine derivative used as a building block in solid-phase peptide synthesis. The compound features a fluorenylmethoxycarbonyl (Fmoc) group for temporary amine protection and a 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) group for guanidine side-chain protection, enabling selective deprotection during peptide assembly.

Protected arginine monomer for Fmoc-based solid-phase peptide synthesisIntermediate for manufacturing custom peptides and peptide-based research compounds

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 154445-77-9

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Related Compounds

SimilarStructure SimilarSimilarity 0.83

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SimilarStructure SimilarSimilarity 0.79

Fmoc-Arg(Pbf)-Ser(Psi(Me,Me)pro)-OH

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N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithine

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Identifiers
IUPAC Name

(2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid

InChIKey

HNICLNKVURBTKV-NDEPHWFRSA-N

SMILES

CC1=C(C(=C(C2=C1OC(C2)(C)C)C)S(=O)(=O)NC(=NCCC[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)N)C

Synonyms (24)
  • Fmoc-Arg(Pbf)-OH
  • Fmoc-L-Arg(Pbf)
  • Fmoc-L-arg(pbf)-OH
  • Na-Fmoc-Nw-Pbf-L-arginine
  • fmoc-arg(pbf)