C20H19N5Na2O6
471.4 g/mol
APIDanger
Pemetrexed disodium
CAS150399-23-8EC604-733-2
Category
API
Compound Class
Organic Acid
Primary Use
Pharmaceutical Raw Material
Pemetrexed disodium is an organic sodium salt that acts as an antimetabolite and antineoplastic agent. It inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, enzymes involved in folate metabolism.
Active pharmaceutical ingredient for antineoplastic formulationsInhibitor of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 150399-23-8
Related Compounds
StrongSame Parent
Pemetrexed disodium heptahydrate
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StrongSame Parent
Pemetrexed disodium hemipentahydrate
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Referencestereoisomer of
D-Pemetrexed disodium
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pharmaceutical raw material
Referencestereoisomer of
Pemetrexed
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active pharmaceutical ingredient
Safety Reference
Danger
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
Identifiers
IUPAC Name
disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
InChIKey
NYDXNILOWQXUOF-GXKRWWSZSA-L
SMILES
C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Synonyms (23)
- Pemetrexed disodium (USAN)
- Alimta
- Alimta (TN)
- Almita
- Disodium, Pemetrexed
- LY 231,514
- LY231514 DISODIUM SALT
- Pemetrexed disodium
- Pemetrexed sodium salt
- Rolazar
- Tifolar