C10H17NO5
231.25 g/mol
Pharmaceutical IntermediateWarning
N-Boc-4-hydroxy-D-proline, trans-
CAS147266-92-0EC959-006-5
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
N-Boc-4-hydroxy-D-proline, trans- is a chiral, protected amino acid derivative used as an intermediate in peptide synthesis. Its structure features a tert-butoxycarbonyl (Boc) protecting group on the pyrrolidine nitrogen and a trans-configured hydroxyl group, making it suitable for incorporating modified proline residues into synthetic peptides.
Peptide synthesis intermediateBuilding block for pharmaceutical research
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
SimilarStructure SimilarSimilarity 0.74
(2S,5S)-1-(tert-Butoxycarbonyl)-5-hydroxypiperidine-2-carboxylic acid
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SimilarStructure SimilarSimilarity 0.74
(2S-trans)-5-Hydroxy-1,2-piperidinedicarboxylic acid 1-(tert-butyl) ester
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SimilarStructure SimilarSimilarity 0.74
(2S,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
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ApplicationSame Use
Boc-L-Glutamic acid
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N-Fmoc-N'-Cbz-L-2,4-diaminobutyric acid
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Fmoc-D-Arginine
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ReferenceSame Category
(R)-2-(Boc-amino)pentane-1,5-diyl Dimethanesulfonate
CAS1473368-47-6
pharmaceutical intermediate
Related Reading
Safety Reference
Warning
H319Causes serious eye irritation
H315Causes skin irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
Identifiers
IUPAC Name
(2R,4S)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
InChIKey
BENKAPCDIOILGV-NKWVEPMBSA-N
SMILES
CC(C)(C)OC(=O)N1C[C@H](C[C@@H]1C(=O)O)O
Synonyms (19)
- BOC-D-HYP-OH
- Boc-trans-D-Hyp-OH
- Ertapenem Impurity C28
Sourcing N-Boc-4-hydroxy-D-proline, trans-?
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