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Home/Compounds/API/Vebreltinib
C20H15F3N8
424.4 g/mol
API

Bozitinib

CAS1440964-89-5
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

Bozitinib, also known as vebreltinib, is an orally bioavailable small-molecule inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor). It selectively binds to c-Met, disrupting its signal transduction pathways and inducing cell death in tumor cells that overexpress or have constitutively activated c-Met.

c-Met inhibitor active pharmaceutical ingredientresearch compound for c-Met signaling studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine

InChIKey

QHXLXUIZUCJRKV-UHFFFAOYSA-N

SMILES

CN1C=C2C=C(C(=CC2=N1)F)C(C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C6CC6)(F)F

Synonyms (14)
  • APL-101
  • CBT-101
  • Vebreltinib (USAN)
  • Bozitinib
  • Bozitinib (PLB-1001)
  • PLB-1001?
  • US9695175, 44
  • Vebreltinib
  • WHO 11677