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Home/Compounds/Pharmaceutical Intermediate/Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
C44H53FN7O8P
857.9 g/mol
Pharmaceutical Intermediate

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS144089-97-4
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a nucleoside phosphoramidite intermediate used in the production of oligonucleotides. It features a complex structure with multiple aromatic rings, ether linkages, and a cyanoethoxy phosphoramidite group, designed for solid-phase DNA/RNA synthesis.

nucleoside phosphoramidite intermediate for oligonucleotide synthesispharmaceutical intermediate for research and manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.89

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SimilarStructure SimilarSimilarity 0.85

5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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SimilarStructure SimilarSimilarity 0.80

2'-dG(iBu)-2'-phosphoramidite

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Identifiers
IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChIKey

KJFUMXZZVYMQEU-AOCJBPQJSA-N

SMILES

CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

Synonyms (23)
  • 2'-F-IBu-G Phosphoramidite
  • Cytidine Impurity 63
  • DMT-2'FLUORO-DG(IB) AMIDITE