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Home/Compounds/Pharmaceutical Intermediate/(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic acid gamama-lactone 3,5-bis(4-chlorobenzoate)
C20H15Cl2FO6
441.2 g/mol
Pharmaceutical Intermediate

((2R,3R,4R)-3-((4-Chlorobenzoyl)oxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl 4-chlorobenzoate

CAS1294481-79-0
Category
Pharmaceutical Intermediate
Compound Class
Ester
Primary Use
Pharmaceutical Intermediate

This compound is a fluorinated lactone derivative bearing two 4-chlorobenzoyl ester groups, serving as a key pharmaceutical intermediate in the manufacturing of sofosbuvir.

Pharmaceutical intermediate for sofosbuvirBuilding block in antiviral drug synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

SimilarStructure SimilarSimilarity 0.79

(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic acid gamma-lactone 3,5-dibenzoate

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pharmaceutical intermediate

ApplicationSame Use

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ReferenceSame Category

[(2R,3R,4R,5R)-5-BROMO-3-(4-CHLOROBENZOYLOXY)-4-FLUORO-4-METHYLOXOLAN-2-YL]METHYL 4-CHLOROBENZOATE

CAS1294481-81-4

pharmaceutical intermediate

ReferenceSame Category

9-[(2R)-3,5-Bis-O-(4-chlorobenzoyl)-2-deoxy-2-fluoro-2-methyl-beta-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-amine

CAS1294481-82-5

pharmaceutical intermediate

ReferenceSame Category

(2R)-1-{5-Amino-2-[1-(benzyloxy)-2-methyl-2-propanyl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)-2-propanol

CAS1294504-67-8

pharmaceutical intermediate

ReferenceSame Category

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS129451-75-8

pharmaceutical intermediate

Referencesame scaffold

2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate

CAS122111-01-7

pharmaceutical intermediate

Identifiers
IUPAC Name

[(2R,3R,4R)-3-(4-chlorobenzoyl)oxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl 4-chlorobenzoate

InChIKey

CTNZBYHJBWVNHD-JXXFODFXSA-N

SMILES

C[C@]1([C@@H]([C@H](OC1=O)COC(=O)C2=CC=C(C=C2)Cl)OC(=O)C3=CC=C(C=C3)Cl)F

Synonyms (9)

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