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Home/Compounds/Pharmaceutical Intermediate/Sulfo-SPDB
C13H14N2O7S3
406.5 g/mol
Pharmaceutical Intermediate

Sulfo-SPDB

CAS1193111-39-5
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

Sulfo-SPDB is a sulfonated heterobifunctional crosslinking reagent used as a pharmaceutical intermediate in the manufacture of antibody-drug conjugates. It features a pyridyl disulfide moiety and an N-hydroxysuccinimide ester, enabling controlled conjugation of cytotoxic payloads to antibodies.

Pharmaceutical intermediate for antibody-drug conjugate (ADC) manufacturingCrosslinking reagent for bioconjugation in drug development

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid

InChIKey

FUHCFUVCWLZEDQ-UHFFFAOYSA-N

SMILES

C1CC(=O)N(C1=O)OC(=O)C(CCSSC2=CC=CC=N2)S(=O)(=O)O

Synonyms (5)
  • sulfo-SPDB