C14H11ClN2O4
306.7 g/mol
APIWarning
Vadadustat
CAS1000025-07-9
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Vadadustat is an orally administered small molecule that inhibits hypoxia-inducible factor prolyl-hydroxylase (HIF-PH), thereby mimicking hypoxic conditions to stimulate erythropoiesis. It is used as an active pharmaceutical ingredient in the management of anemia associated with chronic kidney disease in adults on maintenance dialysis.
active pharmaceutical ingredient for anemia associated with chronic kidney diseaseHIF-PH inhibitor for pharmaceutical manufacturing
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 1000025-07-9
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Safety Reference
Warning
H302Harmful if swallowed
H373May cause damage to organs through prolonged or repeated exposure
Identifiers
IUPAC Name
2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
InChIKey
JGRXMPYUTJLTKT-UHFFFAOYSA-N
SMILES
C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
Synonyms (20)
- B506
- Vadadustat (JAN/USAN/INN)
- AKB-6548; B-506; PG-1016548
- US8598210, 119
- US8598210, Table XV, 10
- US8598210, Table XV, 11
- Vadadustat
- Vafseo
- Vafseo (TN)
- vadadustatum