C24H28N2O3
392.5 g/mol
APIWarning
Ivacaftor
CAS873054-44-5EC800-027-5
Category
API
Compound Class
Amide
Primary Use
Pharmaceutical Raw Material
Ivacaftor is a pharmaceutical raw material used in the manufacturing of medications for cystic fibrosis. It is included in combination products alongside lumacaftor, tezacaftor, and elexacaftor for broader applicability in certain patient populations.
Active pharmaceutical ingredient for cystic fibrosis therapiesComponent in combination drug formulations
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 873054-44-5
Related Compounds
SimilarStructure SimilarSimilarity 0.74
2,4-di-tert-Butyl-5-[(4-oxo-1,4-dihydroquinoline-3-carbonyl)amino]phenyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
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5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine
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ReferenceSame Category
BMS-599626
CAS873837-23-1
pharmaceutical raw material
Referencestereoisomer of
Deutivacaftor
CAS1413431-07-8
pharmaceutical raw material
Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
Identifiers
IUPAC Name
N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide
InChIKey
PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES
CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
Synonyms (24)
- EX-A441
- VX-770
- Ivacaftor (USAN/INN)
- Ivacaftor
- Ivacaftor (VX-770)
- Ivacaftor-d18
- Kalydeco
- Kalydeco (TN)
- ORKAMBI COMPONENT IVACAFTOR
- SYMKEVI COMPONENT IVACAFTOR
- TRIKAFTA COMPONENT IVACAFTOR
- VX-770, Ivacaftor, Kalydeco
- ivacaftorum