C19H16N2O5
352.3 g/mol
APIWarning
Roxadustat
CAS808118-40-3
Category
API
Compound Class
Amide
Primary Use
Pharmaceutical Raw Material
Roxadustat is a compound that inhibits hypoxia-inducible factor prolyl hydroxylase, an enzyme involved in cellular oxygen sensing. It is an N-acylglycine derivative and is used as an active pharmaceutical ingredient in pharmaceutical manufacturing.
EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitorEC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 808118-40-3
Related Compounds
SimilarStructure SimilarSimilarity 0.84
Roxadustat Impurity 2
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Referencesame scaffold
4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid
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Referencesame scaffold
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Referencesame scaffold
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Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
Identifiers
IUPAC Name
2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
InChIKey
YOZBGTLTNGAVFU-UHFFFAOYSA-N
SMILES
CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
Synonyms (22)
- 8HO
- EX-A390
- Roxadustat (JAN/USAN/INN)
- ASP 1517
- Evrenzo
- Evrenzo (TN)
- FG 4592
- FG-4592,ASP1517
- Roxadustat
- Roxadustat (FG-4592)
- Roxadustat (Standard)
- roxadustatum