C19H16N2O5
352.3 g/mol
APIWarning
Roxadustat
CAS808118-40-3
Category
API
Compound Class
Amide
Primary Use
Pharmaceutical Raw Material
Roxadustat is a compound that inhibits hypoxia-inducible factor prolyl hydroxylase, an enzyme involved in cellular oxygen sensing. It is an N-acylglycine derivative and is used as an active pharmaceutical ingredient in pharmaceutical manufacturing.
EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitorEC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
SimilarStructure SimilarSimilarity 0.84
Roxadustat Impurity 2
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Referencesame scaffold
4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid
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pharmaceutical intermediate
Referencesame scaffold
Methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
CAS1421312-34-6
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Referencesame scaffold
4-hydroxy-1-methyl-7-phenoxy-3-Isoquinolinecarboxylic acid ethyl ester
CAS1809286-36-9
research compound
Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
Customs Tariff Classification
The international HS code for Roxadustat (CAS 808118-40-3) is 2933.49.
HS code (international, 6-digit)
2933.49
EU CN code (8-digit)
2933 49 90
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
InChIKey
YOZBGTLTNGAVFU-UHFFFAOYSA-N
SMILES
CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
Synonyms (22)
- 8HO
- EX-A390
- Roxadustat (JAN/USAN/INN)
- ASP 1517
- Evrenzo
- Evrenzo (TN)
- FG 4592
- FG-4592,ASP1517
- Roxadustat
- Roxadustat (FG-4592)
- Roxadustat (Standard)
- roxadustatum
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