C39H67N5O7
718 g/mol
Pharmaceutical IntermediateDanger
Conjugated form of mc-vc-PAB-MMAE
CAS646502-53-6
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
This compound is a conjugated form of the antimitotic agent monomethyl auristatin E (MMAE), linked through a maleimidocaproyl-valine-citrulline-p-aminobenzylcarbamate (mc-vc-PAB) spacer. It is primarily used as an intermediate in the manufacturing of antibody-drug conjugates (ADCs), enabling the stable attachment of the cytotoxic payload to targeting antibodies.
antibody-drug conjugate manufacturing intermediateresearch reagent for ADC development studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 646502-53-6
Related Compounds
StrongStructure SimilarSimilarity 0.87
(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
CAS160800-57-7
pharmaceutical raw material
SimilarStructure SimilarSimilarity 0.78
Monomethyl auristatin F
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ApplicationSame Use
VC-PAB-MMAE
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ReferenceSame Category
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ReferenceSame Category
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ReferenceSame Category
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Referencestereoisomer of
Monomethyl auristatin E
CAS474645-27-7
pharmaceutical intermediate
Safety Reference
Danger
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Identifiers
IUPAC Name
(2S)-N-[(2S)-1-[[(3R,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide
InChIKey
DASWEROEPLKSEI-AWNAIHLBSA-N
SMILES
CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
Synonyms (6)
- PAB-MMAE
- VcMMAE
- Vedotin
- Vedotin radical