C23H30O3
354.5 g/mol
APIDanger
Etretinate
CAS54350-48-0EC259-119-3
Category
API
Compound Class
Ester
Primary Use
Pharmaceutical Raw Material
Etretinate is a second-generation retinoid that was used as an active pharmaceutical ingredient in medications for severe psoriasis. It was developed by Hoffmann–La Roche and approved by the FDA in 1986, but later withdrawn from several markets due to a high risk of birth defects.
pharmaceutical raw material for retinoid-based formulationsreference standard in analytical research
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 54350-48-0
Related Compounds
SimilarStructure SimilarSimilarity 0.83
Butyl 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
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SimilarStructure SimilarSimilarity 0.83
Butyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
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pharmaceutical intermediate
SimilarStructure SimilarSimilarity 0.75
Acitretin Impurity 10
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Safety Reference
Danger
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Identifiers
IUPAC Name
ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
InChIKey
HQMNCQVAMBCHCO-DJRRULDNSA-N
SMILES
CCOC(=O)/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C(=C(C=C1C)OC)C)C
Synonyms (35)
- Acitretin EP Impurity B; Etretinate
- Etretinate (JAN/USAN/INN)
- Etretinato [INN-Spanish]
- Etretinatum [INN-Latin]
- ACITRETIN IMPURITY B
- B10 9359
- ETRETINATE [MART.]
- Ethyl etrinoate
- Etretinate (Standard)
- Etretinato
- Etretinatum
- Etrinoate, Ethyl
- Retinoid
- Ro 10-9359
- TEGISON (TN)
- Tegison
- Tigason
- Tigazon
- etretinate