C18H22O2
270.4 g/mol
APIDanger
Estrone
CAS53-16-7EC200-164-5
Category
API
Compound Class
Steroid
Primary Use
Pharmaceutical Raw Material
Estrone is a naturally occurring estrogen hormone used as an active pharmaceutical ingredient. It plays a key role in hormone replacement therapy and the manufacturing of steroidal compounds.
active pharmaceutical ingredient for hormone therapyintermediate in the synthesis of 19-norsteroids
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
Restricted or banned substances
Substances on this list are banned or restricted under the named regulation. This page is a compliance reference — verify your obligations under applicable law.
Relevant lists:California Proposition 65
CAS 53-16-7
Related Compounds
ReferenceSame Category
(RS)-mitotane
CAS53-19-0
pharmaceutical raw material
ReferenceSame Category
Methylprednisolone acetate
CAS53-36-1
pharmaceutical raw material
ReferenceSame Category
Oxandrolone
CAS53-39-4
pharmaceutical raw material
ReferenceSame Category
Androsterone
CAS53-41-8
pharmaceutical raw material
Referencestereoisomer of
Estrone-2,4,16,16-d4
CAS53866-34-5
research compound
Referencesame scaffold
2,3-Dihydroxy(1,4,16,16-²H₄)estra-1(10),2,4-trien-17-one
CAS81586-97-2
research compound
Referencesame scaffold
3,4-Dihydroxy(1,2,16,16-²H₄)estra-1,3,5(10)-trien-17-one
CAS81586-98-3
research compound
Referencesame scaffold
2-Methoxyestrone-1,4,16,16-d4
CAS949885-90-9
research compound
Safety Reference
Danger
H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
H401Toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Regulatory Compliance1
- California Proposition 65USRegulation
Customs Tariff Classification
The international HS code for Estrone (CAS 53-16-7) is 2937.23.
HS code (international, 6-digit)
2937.23
EU CN code (8-digit)
2937 23 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
InChIKey
DNXHEGUUPJUMQT-CBZIJGRNSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O
Synonyms (121)
- Estradiol Hemihydrate EP Impurity A; Estriol EP Impurity B; Ethinylestradiol EP Impurity C; Estrone
- Estriol EP Impurity B (Estrone)
- Estrona [INN-Spanish]
- Estrone (JAN/USP/INN)
- Estrone, European Pharmacopoeia (EP)
- Estrone, United States Pharmacopeia (USP)
- Estrone, meets USP testing specifications
- Estronum [INN-Latin]
- (+/-)-Oestrone
- 1,3,5-Estratrien-3-ol-17-one
- Aquacrine
- Aquest
- Crinovaryl
- Cristallovar
- Crystogen
- Destrone
- Disynformon
- E(sub 1)
- ESTRONE [MART.]
- ETHINYLESTRADIOL IMPURITY C
- Endofolliculina
- Estradiol metabolite e1
- Estrogenic Substance
- Estron
- Estrona
- Estrona [Spanish]
- Estrone (E1)
- Estrone (Standard)
- Estrone 1.0 mg/ml in Methanol
- Estrone 1516
- Estrone CRS
- Estrone DL-form
- Estrone RS
- Estrone, 15
- Estrone, VETRANAL(TM)
- Estrone-A
- Estronum
- Estrugenone
- Estrusol
- Fem-O-Gen
- Femestrone injection
- Femidyn
- Folikrin
- Folipex
- Folisan
- Follestrine
- Follestrol
- Follicular hormone;
- Folliculine
- Folliculine benzoate
- Folliculinum
- Follicunodis
- Glandubolin
- Hiestrone
- Hormestrin
- Hormofollin
- Hormovarine
- Kestrone
- Ketodestrin
- Ketohydroxy-Estratriene
- Ketohydroxyestrin
- Ketohydroxyoestrin
- Kolpon
- Menagen
- Menformon
- Mestronaq
- Oestrin
- Oestroform
- Oestronum
- Oestroperos
- Ovex (tablets)
- Ovifollin
- Oxohydroxyoestrin;
- Perlatan
- Solliculin
- Theelin
- Thelestrin
- Thelykinin
- Thynestron
- Tokokin
- Unden
- Unden (pharmaceutical)
- Unden (pharmaceutical) (VAN)
- Unigen
- Wynestron
- [2,4,6,7-3H]-E1
- [2,4,6,7-3H]-Estrone
- estrol
- estrone
- estrovarin
- folliculin
- hydroxyestrones