C21H23NO6
385.4 g/mol
APIDanger
O10-Demethylcolchicine
CAS477-27-0EC207-512-5
Category
API
Compound Class
Natural Product
Primary Use
Pharmaceutical Raw Material
Colchiceine is a cyclic ketone and a major metabolite of the anti-gout drug colchicine. It is a naturally occurring compound found in plants such as Colchicum autumnale and is used as a reference standard in pharmaceutical manufacturing and research.
pharmaceutical raw materialresearch compound for gout therapy studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
SimilarStructure SimilarSimilarity 0.85
(S)-(−)-colchicine
CAS64-86-8
pharmaceutical raw material
SimilarStructure SimilarSimilarity 0.85
(R)-colchicine
CAS75520-89-7
pharmaceutical raw material
ReferenceSame Category
Visnadine
CAS477-32-7
pharmaceutical raw material
ReferenceSame Category
Tofacitinib
CAS477600-75-2
pharmaceutical raw material
ReferenceSame Category
Rhein
CAS478-43-3
pharmaceutical raw material
ReferenceSame Category
Gabapentin enacarbil
CAS478296-72-9
pharmaceutical raw material
Safety Reference
Danger
H300Fatal if swallowed
H318Causes serious eye damage
H330Fatal if inhaled
H340May cause genetic defects
Customs Tariff Classification
The international HS code for O10-Demethylcolchicine (CAS 477-27-0) is 2939.79.
HS code (international, 6-digit)
2939.79
EU CN code (8-digit)
2939 79 90
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
InChIKey
PRGILOMAMBLWNG-HNNXBMFYSA-N
SMILES
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)O)OC)OC)OC
Synonyms (30)
- 2SJ
- Colchicine EP Impurity F
- COLCHICINE IMPURITY F
- Coichiceine
- Colchiceine (VAN)
- O(sup 10)-Demethylcolchicine
- O-Demethylcolchicine
- O10-Demethylcolchicine
- colchicein
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