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Home/Compounds/Pharmaceutical Intermediate/N,N-dimethylformamide dimethyl acetal
C5H13NO2
119.16 g/mol
Pharmaceutical IntermediateDanger

N,N-Dimethylformamide dimethyl acetal

CAS4637-24-5EC225-063-3
Category
Pharmaceutical Intermediate
Compound Class
Amine
Primary Use
Pharmaceutical Intermediate

N,N-Dimethylformamide dimethyl acetal is a chemical compound used as a reagent in organic synthesis. Its primary significance is as an intermediate in the Leimgruber–Batcho indole synthesis, where it facilitates the formation of an enamine from o-nitrotoluenes.

Reagent in the Leimgruber–Batcho indole synthesisIntermediate in indole manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Safety Reference

Flammable
Flammable
Corrosive
Corrosive
Harmful
Harmful
Danger
H225Highly flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Customs Tariff Classification

The international HS code for N,N-Dimethylformamide dimethyl acetal (CAS 4637-24-5) is 2922.50.

HS code (international, 6-digit)

2922.50

EU CN code (8-digit)

2922 50 00

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

1,1-dimethoxy-N,N-dimethylmethanamine

InChIKey

ZSXGLVDWWRXATF-UHFFFAOYSA-N

SMILES

CN(C)C(OC)OC

Synonyms (38)
  • DMF-DMA
  • (MeO)2CHNMe2
  • 1,1-Dimethoxytrimethylamine
  • CH(OMe)2NMe2
  • DMF Dimethyl acetal
  • Dimethylaminodimethoxymethane
  • Leflunomide Impurity 15
  • Me2NCH(OMe)2

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