C7H6F3N
161.12 g/mol
Pharmaceutical IntermediateDanger
4-(Trifluoromethyl)aniline
CAS455-14-1EC207-236-5
Category
Pharmaceutical Intermediate
Compound Class
Aromatic
Primary Use
Pharmaceutical Intermediate
4-(Trifluoromethyl)aniline is a substituted aniline characterized by a benzene ring with an amino group at position 1 and a trifluoromethyl group at position 4. It is used as an intermediate in the manufacturing of teriflunomide.
intermediate for teriflunomide synthesislaboratory research reagent
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
ReferenceSame Category
Trifluoro-p-tolunitrile
CAS455-18-5
pharmaceutical intermediate
ReferenceSame Category
4-(Trifluoromethyl)benzaldehyde
CAS455-19-6
pharmaceutical intermediate
ReferenceSame Category
3-Fluorobenzoic acid
CAS455-38-9
pharmaceutical intermediate
ReferenceSame Category
Methyl 3-fluorobenzoate
CAS455-68-5
pharmaceutical intermediate
Safety Reference
Danger
H301Toxic if swallowed
H318Causes serious eye damage
H319Causes serious eye irritation
H331Toxic if inhaled
H372Causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Customs Tariff Classification
The international HS code for 4-(Trifluoromethyl)aniline (CAS 455-14-1) is 2921.43.
HS code (international, 6-digit)
2921.43
EU CN code (8-digit)
2921 43 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
4-(trifluoromethyl)aniline
InChIKey
ODGIMMLDVSWADK-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1C(F)(F)F)N
Synonyms (32)
- 4-TFMA
- Leflunomide EP Impurity A
- Leflunomide impurity A, European Pharmacopoeia (EP)
- 4-(Trifluoromethyl)aniline
- 4-Aminobenzotrifluoride
- 4-Aminobenzotrifluororide
- 4-Trifluoromethyl-phenylamine
- 4-trifluormethylaniline
- Aniline, p-(trifluoromethyl)-
- LEFLUNOMIDE IMPURITY A
- Leflunomide impurity A CRS
- a,a,a-trifluoro-p-toluidine
- aniline, 4-trifluoromethyl-
- p-(Trifluoromethyl)aniline
- p-Aminobenzotrifluoride
- para-aminobenzotrifluoride
- para-trifluoromethylaniline
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