Spliceostatin A is a polyketide natural product and a macrolide antibiotic with activity against Mycobacterium tuberculosis. It functions as an RNA polymerase inhibitor and is structurally more stable than its analogue etnangien.
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
Sourcing Spliceostatin A?
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(2S,3Z)-5-{[(2R,3R,5S,6S)-6-{(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2,4-dien-1-yl}-2,5-dimethyltetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate
pharmaceutical raw material
(2S,3Z)-5-{[(2R,3R,5S,6S)-2,5-dimethyl-6-{(2E,4E)-3-methyl-5-[(3R,4R,5R,7S,8R)-4,7,8-trihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]penta-2,4-dien-1-yl}tetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate
pharmaceutical raw material
(2S,3S)-2,3-Bis((2-methylbenzoyl)oxy)succinic acid
pharmaceutical intermediate
Isonicotinoyl chloride hydrochloride
pharmaceutical intermediate
4-amino-2,3-dichlorophenol
pharmaceutical intermediate
4-Bromo-2,2-diphenylbutanenitrile
pharmaceutical intermediate
Thailanstatin A
pharmaceutical intermediate
Spliceostatin C
research compound
[(Z,2S)-5-[[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4-hydroxy-7-methoxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
XKSGIJNRMWHQIQ-CGPJBNNXSA-N
C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@@](O2)(C)OC)CO3)O)C)NC(=O)/C=C\[C@H](C)OC(=O)C
Sourcing Spliceostatin A?
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