C21H29N6O5P
476.5 g/mol
APIDanger
TENOFOVIR ALAFENAMIDE
CAS379270-37-8
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
Tenofovir alafenamide is a prodrug of tenofovir, a reverse transcriptase inhibitor used in antiviral therapy. It is a phosphoramidate ester derivative formulated for pharmaceutical manufacturing as an active pharmaceutical ingredient.
Active pharmaceutical ingredient in combination therapy for HIV-1 infection
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 379270-37-8
Related Compounds
StrongSame Parent
Tenofovir alafenamide fumarate
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antiviral prodrug for HIV-1
ReferenceSame Category
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pharmaceutical raw material
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pharmaceutical raw material
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pharmaceutical raw material
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11-hydroxy-N-methyldesloratadine
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pharmaceutical raw material
Referencestereoisomer of
Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate
CAS383365-04-6
pharmaceutical raw material
Referencestereoisomer of
Isopropyl ((s)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate
CAS2053424-82-9
pharmaceutical intermediate
Referencestereoisomer of
Isopropyl ((r)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-d-alaninate
CAS2053424-88-5
research compound
Safety Reference
Danger
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
Identifiers
IUPAC Name
propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
InChIKey
LDEKQSIMHVQZJK-CAQYMETFSA-N
SMILES
C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3
Synonyms (24)
- Tenofovir alafenamide (USAN/INN)
- GS-7340 Tenofovir alafenamide
- GS-7340?
- TENOFOVIR ALAFENAMIDE
- TFV Alafenamide
- Tenofovir alafenamida
- US12049474, Compound TAF
- Vemlidy