C8H5F3N2
186.13 g/mol
Pharmaceutical IntermediateDanger
4-amino-3-(trifluoromethyl)benzonitrile
CAS327-74-2EC675-039-5
Category
Pharmaceutical Intermediate
Compound Class
Amine
Primary Use
Pharmaceutical Intermediate
4-Amino-3-(trifluoromethyl)benzonitrile is a cyanated and trifluoromethylated derivative of aniline. It serves as a key starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide, a pharmaceutical intermediate.
Pharmaceutical intermediate for bicalutamide synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 327-74-2
Related Compounds
ApplicationSame Use
P-aminobenzonitrile
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ReferenceSame Category
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
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ReferenceSame Category
3,5-Bis(trifluoromethyl)benzyl alcohol
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pharmaceutical intermediate
ReferenceSame Category
2-Oxo-1-benzimidazolinebutyric acid
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ReferenceSame Category
5-(4-Chlorophenyl)-6-methylpyrimidine-2,4(1H,3H)-diimine
CAS3275-44-3
pharmaceutical intermediate
Safety Reference
Danger
H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
Identifiers
IUPAC Name
4-amino-3-(trifluoromethyl)benzonitrile
InChIKey
MWLZJOBGDXBMBP-UHFFFAOYSA-N
SMILES
C1=CC(=C(C=C1C#N)C(F)(F)F)N
Synonyms (9)
- Bicalutamide Impurity 54