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Home/Compounds/Pharmaceutical Intermediate/5'(E)-VP-2 inverted exclamation mark -F-U-CE-Phoshoramidite
C32H51FN4O12P2
764.7 g/mol
Pharmaceutical Intermediate

5'(E)-VP-2 inverted exclamation mark -F-U-CE-Phoshoramidite

CAS2923487-59-4
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a nucleotide phosphoramidite building block used in the synthesis of modified oligonucleotides. It features a protected phosphate group with pivaloyloxymethyl (POM) masking groups and a fluorinated sugar moiety, designed for the chemical synthesis of nucleic acid analogs.

Building block for oligonucleotide synthesisChemical intermediate for modified DNA constructs

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

SimilarStructure SimilarSimilarity 0.73

((((E)-2-((2R,3R,4R,5R)-3-(((2-CYANOETHOXY)(DIISOPROPYLAMINO)PHOSPHINO)OXY)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-METHOXYTETRAHYDROFURAN-2-YL)VINYL)PHOSPHORYL)BIS(OXY))BIS(METHYLENE) BIS(2,2-DIMETHYLPROPANOATE)

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Identifiers
IUPAC Name

[[(Z)-2-[(2R,3R,4R,5R)-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyloxolan-2-yl]ethenyl]-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

InChIKey

AKBGYKGPJKZIJW-OHBQVFRMSA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@]1(C)F)N2C=CC(=O)NC2=O)/C=C\P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C

Synonyms (1)

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