C24H27Cl3FN5O3
558.9 g/mol
APIWarning
Canertinib dihydrochloride
CAS289499-45-2EC663-691-3
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Canertinib dihydrochloride is the hydrochloride salt of an orally bioavailable quinazoline compound. It acts as an irreversible inhibitor of epidermal growth factor receptor (ErbB family) tyrosine kinases, and has been investigated for its potential antineoplastic and radiosensitizing activities.
Active pharmaceutical ingredient for cancer researchRadiosensitizing agent in experimental studiesSynergistic agent with other chemotherapeutic compounds in research
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Identifiers
IUPAC Name
N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;dihydrochloride
InChIKey
JZZFDCXSFTVOJY-UHFFFAOYSA-N
SMILES
C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
Synonyms (17)
- Canertinib dihydrochloride (USAN)
- 289499-45-2 (HCl)
- CANERTINIB HYDROCHLORIDE
- CI-1033, >=98% (HPLC)
- Canertinib 2HCl
- Canertinib HCl
- Canertinib dihydrochloride
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