C6H6F3N5O
221.14 g/mol
Pharmaceutical IntermediateWarning
7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine; 7-nitroso-3-(trifluoromethyl)-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine
CAS2892260-32-9EC959-938-2
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate
This compound is a nitrosamine impurity associated with the pharmaceutical compound sitagliptin. It is primarily recognized as a process-related impurity in pharmaceutical manufacturing and quality control.
Reference standard for nitrosamine impurity analysisQuality control in sitagliptin manufacturing
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 2892260-32-9
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Referencesame scaffold
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
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Referencesame scaffold
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
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Safety Reference
Warning
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
Identifiers
IUPAC Name
7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine
InChIKey
HPLUAAVIJHAQQZ-UHFFFAOYSA-N
SMILES
C1CN2C(=NN=C2C(F)(F)F)CN1N=O
Synonyms (12)
- NTTP
- Nitroso-sitagliptin STG-19
- Sitagliptin Nttp Impurity