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Home/Compounds/Pharmaceutical Intermediate/(2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one
C21H19F6NO3
447.4 g/mol
Pharmaceutical Intermediate

(2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

CAS287930-75-0
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a pharmaceutical intermediate used in the synthesis of NK1 receptor antagonists such as aprepitant. It features a complex stereochemically defined structure with aromatic rings, ether linkages, and halogen substituents, making it a key building block in manufacturing processes.

intermediate for NK1 receptor antagonist synthesisresearch compound for pharmaceutical manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 287930-75-0

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Identifiers
IUPAC Name

(2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

InChIKey

KVPJNHLVRGUYGQ-BFUOFWGJSA-N

SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2C(=O)N(CCO2)CC3=CC=CC=C3

Synonyms (6)
  • Aprepitant Impurity 23
  • Fosaprepitant Impurity B