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Home/Compounds/API/Sevabertinib
C24H25ClN4O5
484.9 g/mol
API

Sevabertinib

CAS2521285-05-0
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

Sevabertinib is a reversible kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2) and exhibits activity against epidermal growth factor receptor (EGFR). It is indicated for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain activating mutations, and received accelerated FDA approval in November 2025.

Reversible HER2/EGFR kinase inhibitor for non-squamous non-small cell lung cancer with HER2 activating mutations

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Customs Tariff Classification

The international HS code for Sevabertinib (CAS 2521285-05-0) is 2934.99.

HS code (international, 6-digit)

2934.99

EU CN code (8-digit)

2934 99 90

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

3-(3-chloro-2-methoxyanilino)-2-[3-[[(2S)-1,4-dioxan-2-yl]methoxy]-4-pyridinyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

InChIKey

VYQVHWNNPKOJEA-AWEZNQCLSA-N

SMILES

COC1=C(C=CC=C1Cl)NC2=C(NC3=C2C(=O)NCC3)C4=C(C=NC=C4)OC[C@@H]5COCCO5

Synonyms (14)
  • A1JBI
  • Sevabertinib (USAN)
  • BAY 2927088
  • Example 2
  • Hyrnuo
  • Sevabertinib anhydrous
  • sevabertinib

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