C8H9NO3
167.16 g/mol
APIWarning
D-4-Hydroxyphenylglycine
CAS22818-40-2EC245-247-7
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
D-4-Hydroxyphenylglycine is a non-proteogenic amino acid and a key structural component of vancomycin and related glycopeptide antibiotics. It is produced via the shikimic acid pathway and serves as a pharmaceutical intermediate in antibiotic manufacturing.
antibiotic intermediatebuilding block for glycopeptide antibiotics
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
ApplicationSame Use
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Referencestereoisomer of
Oxfenicine
CAS32462-30-9
pharmaceutical intermediate
Referencestereoisomer of
4-hydroxyphenylglycine
CAS938-97-6
pharmaceutical intermediate
Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Customs Tariff Classification
The international HS code for D-4-Hydroxyphenylglycine (CAS 22818-40-2) is 2922.50.
HS code (international, 6-digit)
2922.50
EU CN code (8-digit)
2922 50 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid
InChIKey
LJCWONGJFPCTTL-SSDOTTSWSA-N
SMILES
C1=CC(=CC=C1[C@H](C(=O)O)N)O
Synonyms (52)
- GHP
- Amoxicillin EP Impurity I; Cefprozil EP Impurity A; Cefadroxil EP Impurity A
- Cefadroxil EP Impurity A(Amoxicillin EP Impurity I)
- Cefprozil EP Impurity A
- Cefprozil impurity A, European Pharmacopoeia (EP)
- D-alpha-(4-Hydroxy-phenyl)glycine, European Pharmacopoeia (EP)
- (R)-(4-HYDROXYPHENYL)GLYCINE
- 4-Hydroxy-D-phenylglycine
- AMOXICILLIN IMPURITY I
- CEFADROXIL IMPURITY A
- CEFPROZIL IMPURITY A
- Cefprozil impurity A CRS
- D-4-Hydroxyphenylglycine
- D-N-(4-Hydroxyphenyl)glycine
- D-P-HYDROXYPHENYLGLYCINE
- D-PHG(4-OH)-OH
- H-D-PHG(4-OH)-OH
- L-P-HYDROXYPHENYGLYCINE
- P-hydroxy-(R)-phenylglycine
- d-4-hydroxyphenylglicyne
- p-Hydroxyphenyl glycine HCl
- p-hydroxy-D-phenylglycine
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