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Home/Compounds/Research Reagent/N-Acetyltryptophyl-alpha-glutamylhistidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-alpha-asparagine
C38H37F3N8O11
838.7 g/mol
Research Reagent

Ac-WEHD-AFC

CAS210344-99-3
Category
Research Reagent
Compound Class
Peptide
Primary Use
Research Compound

Ac-WEHD-AFC is a fluorogenic substrate specifically designed for caspase assays, commonly used in apoptosis research. It contains a tetrapeptide sequence (Ac-WEHD) linked to a fluorescent AFC (7-amino-4-trifluoromethylcoumarin) reporter group, which upon enzymatic cleavage releases a fluorescent signal.

fluorogenic substrate for caspase assayapoptosis research reagent

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

(4S)-4-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

InChIKey

NEGOLAGPKZGIKJ-DZUOILHNSA-N

SMILES

CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CC(=O)O)C(=O)NC4=CC5=C(C=C4)C(=CC(=O)O5)C(F)(F)F

Synonyms (9)
  • Ac-WEHD-AFC