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Home/Compounds/Research Reagent/PE 22-28
C35H55N11O9
773.9 g/mol
Research Reagent

PE 22-28

CAS1801959-12-5
Category
Research Reagent
Compound Class
Peptide
Primary Use
Research Compound

PE 22-28 is a heptapeptide fragment of the endogenous TREK-1 antagonist spadin. It is the smallest identified fragment that retains TREK-1 inhibitory activity and has been investigated in research as a potential antidepressant.

research compound for TREK-1 inhibition studieslaboratory reagent for antidepressant mechanism research

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

InChIKey

CMNBQRXBBJQIOA-YIHYGEMESA-N

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)CNC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN

Synonyms (4)
  • PE 22-28
  • PE 22-28 (acetate)