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Home/Compounds/API/Fosaprepitant
C23H22F7N4O6P
614.4 g/mol
API

Fosaprepitant

CAS172673-20-0
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

Fosaprepitant is a prodrug of aprepitant, formulated as a phosphoramide derivative. It functions as a neurokinin-1 receptor antagonist and is used as an antiemetic in pharmaceutical manufacturing.

Pharmaceutical raw material for antiemetic formulationsProdrug for neurokinin-1 receptor antagonist manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongSame Parent

Fosaprepitant dimeglumine

CAS265121-04-8

pharmaceutical raw material

SimilarStructure SimilarSimilarity 0.73

Aprepitant

CAS170729-80-3

pharmaceutical raw material

ReferenceSame Category

7-Chloro-1-methyl-5-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one

CAS17311-35-2

pharmaceutical raw material

ReferenceSame Category

Butafosfan

CAS17316-67-5

pharmaceutical raw material

ReferenceSame Category

Clomipramine hydrochloride

CAS17321-77-6

pharmaceutical raw material

ReferenceSame Category

Aliskiren

CAS173334-57-1

pharmaceutical raw material

Identifiers
IUPAC Name

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid

InChIKey

BARDROPHSZEBKC-OITMNORJSA-N

SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F

Synonyms (16)
  • Fosaprepitant (INN)
  • FOSAPREPITANT [MART.]
  • Fosaprepitant
  • L-758,298
  • L785,298
  • fosaprepitant-dimeglumine
  • fosaprepitantum