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Home/Compounds/API/Fosbretabulin disodium
C18H19Na2O8P
440.3 g/mol
API

Fosbretabulin disodium

CAS168555-66-6
Category
API
Compound Class
Aromatic
Primary Use
Pharmaceutical Raw Material

Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum). It functions as a prodrug that is dephosphorylated to the active metabolite combretastatin A4, a microtubule-depolymerizing agent that disrupts tumor vasculature, leading to reduced blood flow and ischemic necrosis in tumor tissue.

pharmaceutical raw material for vascular disrupting antineoplastic agentsresearch compound for microtubule disruption studieslaboratory reagent for angiogenesis inhibition studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

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Conivaptan hydrochloride

CAS168626-94-6

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(R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

CAS168828-84-0

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ReferenceSame Category

Pnu-105368

CAS168828-90-8

pharmaceutical raw material

ReferenceSame Category

TAS-115 mesylate

CAS1688673-09-7

pharmaceutical raw material

Identifiers
IUPAC Name

disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate

InChIKey

VXNQMUVMEIGUJW-XNOMRPDFSA-L

SMILES

COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

Synonyms (18)
  • CA-4DP
  • Fosbretabulin disodium (USAN)
  • CA 4P
  • Fosbretabulin Disodium Salt
  • Fosbretabulin disodium

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