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Home/Compounds/API/[2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone
C18H13ClF4N6O
440.8 g/mol
API

Methanone, (2-chloro-3-(trifluoromethyl)phenyl)((4R)-1-(5-fluoro-2-pyrimidinyl)-1,4,6,7-tetrahydro-4-methyl-5H-1,2,3-triazolo(4,5-C)pyridin-5-yl)-

CAS1627902-21-9
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

JNJ-54175446 is a research compound being investigated in clinical trials as a brain-permeable P2X7 antagonist. It is studied for its effects on amyloid biomarkers and cytokine profiles in the cerebrospinal fluid and plasma of healthy participants.

research reagent for P2X7 antagonism studiespharmaceutical raw material for clinical trial supply

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

[2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone

InChIKey

CWFVVQFVGMFTBD-SECBINFHSA-N

SMILES

C[C@@H]1C2=C(CCN1C(=O)C3=C(C(=CC=C3)C(F)(F)F)Cl)N(N=N2)C4=NC=C(C=N4)F

Synonyms (9)
  • US9464084, 158