C6H9N3O3
171.15 g/mol
APIDanger
6-diazo-5-oxo-L-norleucine
CAS157-03-9
Category
API
Compound Class
Other
Primary Use
Pharmaceutical Raw Material
6-Diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that acts as a broad inhibitor of various glutamine-utilizing enzymes. It is an antineoplastic antibiotic originally isolated from a species of Streptomyces and functions as a glutamine antagonist, interfering with glutamine metabolism.
glutamine antagonist antineoplastic antibioticinhibitor of glutamine-utilizing enzymes in researchantimetabolite for laboratory studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 157-03-9
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Safety Reference
Danger
H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
Identifiers
IUPAC Name
(2S)-2-amino-6-diazo-5-oxohexanoic acid
InChIKey
YCWQAMGASJSUIP-YFKPBYRVSA-N
SMILES
C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N
Synonyms (16)
- L-DON
- 6-diazo-5-oxo-L-norleucine
- DON (pharmaceutical)
- H-6-Diazo-5-oxo-Nle-OH
- L-6-Diazo-5-oxonorleucine
- L-Nle(6-Diazo-5-oxo)-OH
- L-Norleucine, 6-diazo-5-oxo-
- Norleucine, 6-diazo-5-oxo, L-
- Norleucine, 6-diazo-5-oxo-
- diazooxonorleucine