C21H19FN6O2
406.4 g/mol
APIWarning
Lorlatinib
CAS1454846-35-5
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Lorlatinib is an active pharmaceutical ingredient used in the manufacture of medications for non-small cell lung cancer. It acts as an inhibitor of anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (ROS1), making it a compound for targeted cancer research and pharmaceutical production.
pharmaceutical manufacturingtargeted cancer researchALK/ROS1 inhibitor development
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
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Safety Reference
Warning
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Customs Tariff Classification
The international HS code for Lorlatinib (CAS 1454846-35-5) is 2934.99.
HS code (international, 6-digit)
2934.99
EU CN code (8-digit)
2934 99 90
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
InChIKey
IIXWYSCJSQVBQM-LLVKDONJSA-N
SMILES
C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
Synonyms (21)
- Lorlatinib (JAN/USAN/INN)
- 4cli
- 4clj
- Loratinib
- Lorbrena
- Lorbrena (TN)
- Lorlatinib
- Lorlatinib (PF-06463922)
- Lorlatinib (Standard)
- Lorviqua
- PF06463922(Lorlatinib)
- PFE-PKIS 10
- lorlatinibum
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