C30H31F3N4O3
552.6 g/mol
Research ReagentWarning
DDR1-IN-1
CAS1449685-96-4
Category
Research Reagent
Compound Class
Amide
Primary Use
Research Compound
DDR1-IN-1 is a research compound that acts as a potent inhibitor of discoidin domain receptor tyrosine kinases 1 and 2 (DDR1/2), with IC50 values of 105 nM and 413 nM, respectively. It is a secondary carboxamide formed from a substituted benzoic acid and an indolone derivative.
DDR1/2 kinase inhibition researchBiochemical tool for studying discoidin domain receptor signaling
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 1449685-96-4
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Safety Reference
Warning
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
Identifiers
IUPAC Name
4-[(4-ethylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(2-oxo-1,3-dihydroindol-5-yl)oxy]phenyl]-3-(trifluoromethyl)benzamide
InChIKey
AOZPVMOOEJAZGK-UHFFFAOYSA-N
SMILES
CCN1CCN(CC1)CC2=C(C=C(C=C2)C(=O)NC3=CC(=C(C=C3)C)OC4=CC5=C(C=C4)NC(=O)C5)C(F)(F)F
Synonyms (9)
- DDR-IN-1
- TL4-44
- DDR1-IN-1