Nerandomilast is a phosphodiesterase 4 (PDE4) inhibitor that preferentially targets the PDE4B subtype. It is an R-stereoisomer with one chiral center, and it exerts anti-fibrotic and immunomodulatory effects by elevating intracellular cAMP levels.
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CAS 1423719-30-5
[1-[[(5R)-2-[4-(5-chloropyrimidin-2-yl)piperidin-1-yl]-5-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino]cyclobutyl]methanol
UHYCLWAANUGUMN-SSEXGKCCSA-N
C1CC(C1)(CO)NC2=NC(=NC3=C2[S@](=O)CC3)N4CCC(CC4)C5=NC=C(C=N5)Cl