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Home/Compounds/API/3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
C21H22Cl2FN5O
450.3 g/mol
API

(S)-crizotinib

CAS1374356-45-2
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material

(S)-crizotinib is an active pharmaceutical ingredient used in the manufacturing of anticancer medications. It functions as a tyrosine kinase inhibitor targeting c-Met/HGFR, ALK, and ROS1, primarily for research and pharmaceutical production related to non-small cell lung carcinoma.

pharmaceutical raw material for targeted cancer therapyresearch compound for tyrosine kinase inhibition studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

SimilarStructure SimilarSimilarity 0.73

4-[4-[6-Amino-5-[[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]oxy]pyridin-3-yl]pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester

CAS877399-51-4

pharmaceutical intermediate

ReferenceSame Category

Ribociclib succinate

CAS1374639-75-4

pharmaceutical raw material

ReferenceSame Category

Rociletinib

CAS1374640-70-6

pharmaceutical raw material

ReferenceSame Category

Trilaciclib

CAS1374743-00-6

pharmaceutical raw material

ReferenceSame Category

NB-124 sulfate

CAS1375073-94-1

pharmaceutical raw material

Referencestereoisomer of

Crizotinib

CAS877399-52-5

pharmaceutical raw material

Identifiers
IUPAC Name

3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

InChIKey

KTEIFNKAUNYNJU-LBPRGKRZSA-N

SMILES

C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Synonyms (13)
  • VHS
  • (S)-Crizotinib, >=98% (HPLC)
  • (S)-crizotinib
  • (S)-crizotinibent-crizotinib
  • Crizotinib S-Isomer
  • crizotinib-(S)
  • ent-crizotinib