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Home/Compounds/Pharmaceutical Intermediate/2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate
C21H20Cl2N2O5S
483.4 g/mol
Pharmaceutical Intermediate

Ketoconazole impurity E

CAS134071-44-6EC603-791-6
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

Ketoconazole impurity E is a pharmaceutical intermediate used in the manufacturing of the antifungal drug ketoconazole. It is a tosylate ester derivative with a complex dioxolane structure containing dichlorophenyl and imidazole groups.

Pharmaceutical intermediate for ketoconazole synthesisReference standard for impurity testing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

ReferenceSame Category

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CAS13433-00-6

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Atorvastatin tert-butyl ester

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pharmaceutical intermediate

ReferenceSame Category

N-ethyl-3-piperidinol

CAS13444-24-1

pharmaceutical intermediate

ReferenceSame Category

Tert-Butyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate

CAS134441-61-5

pharmaceutical intermediate

Customs Tariff Classification

The international HS code for Ketoconazole impurity E (CAS 134071-44-6) is 2934.99.

HS code (international, 6-digit)

2934.99

EU CN code (8-digit)

2934 99 90

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

[(2R,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate

InChIKey

WAXNIYHZFWRPGS-UTKZUKDTSA-N

SMILES

CC1=CC=C(C=C1)S(=O)(=O)OC[C@H]2CO[C@](O2)(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl

Synonyms (18)
  • KETOCONAZOLE IMPURITY E (EP IMPURITY)
  • Ketoconazole EP Impurity E
  • Cis-Tosylate
  • Ketoconazole impurity E

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