Home/Compounds/Pharmaceutical Intermediate/Tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
C16H33NO4Si
331.52 g/mol
Pharmaceutical IntermediateWarning
Tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS114676-67-4EC889-983-2
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate
This compound is a protected derivative of hydroxyproline used as a building block in peptide synthesis. Its structure includes a tert-butyloxycarbonyl (Boc) protecting group and a tert-butyldimethylsilyl (TBDMS) ether, which shield reactive sites during the assembly of peptide chains.
Building block for solid-phase peptide synthesisIntermediate in the preparation of modified peptides
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 114676-67-4
Related Compounds
ReferenceSame Category
Methyl cis-1-Boc-4-hydroxy-D-prolinate
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ReferenceSame Category
(2S,4R)-1-tert-Butyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1,2-dicarboxylate
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pharmaceutical intermediate
ReferenceSame Category
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ReferenceSame Category
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Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Identifiers
IUPAC Name
tert-butyl (2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
InChIKey
IIITUHPEBILIQR-QWHCGFSZSA-N
SMILES
CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1CO)O[Si](C)(C)C(C)(C)C
Synonyms (17)
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