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Home/Compounds/Pharmaceutical Intermediate/Trimethylsilylacetylene
C5H10Si
98.22 g/mol
Pharmaceutical IntermediateDanger

Ethynyltrimethylsilane

CAS1066-54-2EC213-919-9
Category
Pharmaceutical Intermediate
Compound Class
Organometallic
Primary Use
Pharmaceutical Intermediate

Ethynyltrimethylsilane is a silyl-protected terminal alkyne building block widely used in pharmaceutical intermediate manufacturing. Its conserved structure enables selective chemical transformations in research and industrial synthesis.

Pharmaceutical intermediate building blockReagent for alkyne coupling reactionsProtecting group for terminal alkynes in organic synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Safety Reference

Flammable
Flammable
Corrosive
Corrosive
Harmful
Harmful
Danger
H225Highly flammable liquid and vapour
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation

Customs Tariff Classification

The international HS code for Ethynyltrimethylsilane (CAS 1066-54-2) is 2931.90.

HS code (international, 6-digit)

2931.90

EU CN code (8-digit)

2931 90 00

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

ethynyl(trimethyl)silane

InChIKey

CWMFRHBXRUITQE-UHFFFAOYSA-N

SMILES

C[Si](C)(C)C#C

Synonyms (26)
  • TMSA
  • (Trimethylsilyl)acetylene-d
  • (trimethylsily)acetylene
  • 1-(Trimethylsilyl)acetylene
  • 1-Trimethylsilylethyne
  • 1-ethynyl(trimethyl)silane
  • 2-trimethylsilylacetylene
  • Acetylene, trimethylsilyl-
  • Ethyne,-trimethylsilyl
  • Ethynyltrimethylsilane
  • Silane, ethynyltrimethyl-
  • Silane, trimethyl-, ethynyl-
  • TMS acetylene
  • Trimethylethynylsilane
  • Trimethylsilylacetylene
  • Trimetylsilylacetylene
  • ethinyltrimethylsilane
  • ethynyitrimethylsilane
  • tms-acetylide
  • trimethlysilylacetylene
  • trimethylsilanylacetylene
  • trimethylsilanylethyne
  • trimethylsilyl acetylide
  • trimethylsilylacetylen
  • trimethylsilylethyne
  • trimethysilyl acetylene

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