C35H48ClN3O10S
738.3 g/mol
Ingrediente ativo (API)Perigo
Mertansine
CAS139504-50-0
Categoria
Ingrediente ativo (API)
Classe do Composto
Produto natural
Uso Principal
Matéria-prima farmacêutica
Mertansine, also known as DM1, is a thiol-containing maytansinoid used as a payload in antibody-drug conjugates (ADCs), where it is attached to a monoclonal antibody via a linker for targeted delivery.
pharmaceutical intermediate for ADC manufacturingresearch compound for targeted cancer therapy studies
Escopo do conteúdo: As informações desta página dizem respeito à identificação química e aos contextos de fornecimento industrial, pesquisa e produção. Não constituem alegação terapêutica, aconselhamento médico ou instruções de uso de medicamentos.
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CAS 139504-50-0
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Referência de Segurança
Perigo
H300Fatal if swallowed
H310Fatal in contact with skin
H314Causes severe skin burns and eye damage
H340May cause genetic defects
H341Suspected of causing genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
Identificadores
Nome IUPAC
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate
InChIKey
ANZJBCHSOXCCRQ-FKUXLPTCSA-N
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)\C)OC)(NC(=O)O2)O
Sinônimos (13)
- DM 1
- DM1 [Maytansinoid]
- Maytansinoid DM 1
- Mertansine
- Mertansine (DM1 Compound)
- Mertansine (DM1)
- Mertasine