6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine

PLX5622 is a highly selective, brain-penetrant, orally active inhibitor of colony-stimulating factor 1 receptor (CSF1R), used in research to enable prolonged and specific elimination of microglial cells. It is primarily administered via a feed-free diet and exhibits favorable pharmacokinetic properties in various animal models.