C39H67N5O7
718 g/mol
Intermediário farmacêuticoPerigo
Monomethyl auristatin E
CAS474645-27-7
Categoria
Intermediário farmacêutico
Classe do Composto
Peptídeo
Uso Principal
Intermediário farmacêutico
Monomethyl auristatin E is a complex peptide-based compound used as a pharmaceutical intermediate in the manufacturing of antibody-drug conjugates. Its structure features multiple amide groups, an aromatic ring, and several chiral centers, contributing to its role as a key building block in targeted therapeutic development.
pharmaceutical intermediate for antibody-drug conjugate manufacturing
Escopo do conteúdo: As informações desta página dizem respeito à identificação química e aos contextos de fornecimento industrial, pesquisa e produção. Não constituem alegação terapêutica, aconselhamento médico ou instruções de uso de medicamentos.
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CAS 474645-27-7
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Referência de Segurança
Perigo
H300Fatal if swallowed
H330Fatal if inhaled
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
Identificadores
Nome IUPAC
(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide
InChIKey
DASWEROEPLKSEI-UIJRFTGLSA-N
SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
Sinônimos (22)
- 4Q5
- MMAE
- MMAE peptide
- Monomethyl auristatin E
- Monomethyl auristatin E (GMP)
- [3H]-Vedotin