2'-O,4'-C-Methylenecytidine is a locked nucleic acid (LNA) nucleoside analog used as a pharmaceutical raw material in the synthesis of oligonucleotides. It is a key intermediate in the production of compounds such as miravirsen, which has been investigated for research applications.
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LNA-Adenosine
pharmaceutical intermediate
N-(9-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-9H-purin-6-yl)benzamide
modified nucleoside intermediate for oligonucleotide synthesis
(1R,3R,4R,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
oligonucleotide building block
(1R,3R,4R,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-3H-purin-9(6H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
Oligonucleotide synthesis phosphoramidite building block
5-Methyl-2'-o,4'-C-methylenecytidine
nucleoside analogue intermediate
4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidin-2-one
FCMRQQIZHFHCNG-JIOCBJNQSA-N
C1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=CC(=NC3=O)N)O)CO
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