Conjugated form of mc-vc-PAB-MMAE

CAS646502-53-6

용도 분류

의약 중간체

화합물 분류

펩타이드

주요 용도

의약 중간체

This compound is a conjugated form of the antimitotic agent monomethyl auristatin E (MMAE), linked through a maleimidocaproyl-valine-citrulline-p-aminobenzylcarbamate (mc-vc-PAB) spacer. It is primarily used as an intermediate in the manufacturing of antibody-drug conjugates (ADCs), enabling the stable attachment of the cytotoxic payload to targeting antibodies.

antibody-drug conjugate manufacturing intermediateresearch reagent for ADC development studies

콘텐츠 범위: 이 페이지의 정보는 화학물질 식별 및 산업 공급·연구개발·제조 맥락을 대상으로 합니다. 치료 효능 주장, 의료 조언 또는 의약품 사용 지침에 해당하지 않습니다.

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CAS 646502-53-6

안전 참조

독성

유해

위험

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

식별자

IUPAC 이름

(2S)-N-[(2S)-1-[[(3R,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide

InChIKey

DASWEROEPLKSEI-AWNAIHLBSA-N

SMILES

CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC

동의어 목록 (6)

PAB-MMAE
VcMMAE
Vedotin
Vedotin radical

Conjugated form of mc-vc-PAB-MMAE

관련 화합물

안전 참조