Monomethyl auristatin E

CAS474645-27-7

용도 분류

의약 중간체

화합물 분류

펩타이드

주요 용도

의약 중간체

Monomethyl auristatin E is a complex peptide-based compound used as a pharmaceutical intermediate in the manufacturing of antibody-drug conjugates. Its structure features multiple amide groups, an aromatic ring, and several chiral centers, contributing to its role as a key building block in targeted therapeutic development.

pharmaceutical intermediate for antibody-drug conjugate manufacturing

콘텐츠 범위: 이 페이지의 정보는 화학물질 식별 및 산업 공급·연구개발·제조 맥락을 대상으로 합니다. 치료 효능 주장, 의료 조언 또는 의약품 사용 지침에 해당하지 않습니다.

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CAS 474645-27-7

안전 참조

독성

유해

건강 유해

환경 유해

위험

H300Fatal if swallowed

H330Fatal if inhaled

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H340May cause genetic defects

H341Suspected of causing genetic defects

H360May damage fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

식별자

IUPAC 이름

(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide

InChIKey

DASWEROEPLKSEI-UIJRFTGLSA-N

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC

동의어 목록 (22)

4Q5
MMAE
MMAE peptide
Monomethyl auristatin E
Monomethyl auristatin E (GMP)
[3H]-Vedotin

Monomethyl auristatin E

관련 화합물

안전 참조