This compound is a research reagent designed as a linker-payload for antibody-drug conjugates, combining a protease-cleavable valine-citrulline linker with a duocarmycin-based cytotoxic agent. Its structure includes a maleimide group for antibody conjugation, a self-immolative para-aminobenzyl carbamate spacer, and a DNA-alkylating duocarmycin moiety, and is presented as a chloride salt.
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CAS 2055896-98-3
DCTP
nucleotide triphosphate for DNA synthesis
4-Amino-5-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)thieno[2,3-b]pyridin-6(7H)-one
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[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl-[2-[[2-[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indole-3-carbonyl]-1H-indol-5-yl]oxy]ethyl]-dimethylazanium chloride
UNCKJRMATSMWHA-QMUBXYOZSA-N
CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)C[N+](C)(C)CCOC2=CC3=C(C=C2)NC(=C3)C(=O)N4C[C@H](C5=C4C=C(C6=CC=CC=C65)O)CCl)NC(=O)CCCCCN7C(=O)C=CC7=O.[Cl-]