C35H48ClN3O10S
738.3 g/mol
Aktif Farmasötik İngredientTehlike
Mertansine
CAS139504-50-0
Kategori
Aktif Farmasötik İngredient
Bileşik Sınıfı
Doğal Ürün
Birincil Kullanım
Farmasötik ham madde
Mertansine, also known as DM1, is a thiol-containing maytansinoid used as a payload in antibody-drug conjugates (ADCs), where it is attached to a monoclonal antibody via a linker for targeted delivery.
pharmaceutical intermediate for ADC manufacturingresearch compound for targeted cancer therapy studies
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CAS 139504-50-0
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Güvenlik Referansı
Tehlike
H300Fatal if swallowed
H310Fatal in contact with skin
H314Causes severe skin burns and eye damage
H340May cause genetic defects
H341Suspected of causing genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
Tanımlayıcılar
IUPAC Adı
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate
InChIKey
ANZJBCHSOXCCRQ-FKUXLPTCSA-N
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)\C)OC)(NC(=O)O2)O
Eş Anlamlılar (13)
- DM 1
- DM1 [Maytansinoid]
- Maytansinoid DM 1
- Mertansine
- Mertansine (DM1 Compound)
- Mertansine (DM1)
- Mertasine