C35H48ClN3O10S
738.3 g/mol
Principe actif (API)Danger
Mertansine
CAS139504-50-0
Catégorie
Principe actif (API)
Classe du Composé
Produit naturel
Utilisation principale
Matière première pharmaceutique
Mertansine, also known as DM1, is a thiol-containing maytansinoid used as a payload in antibody-drug conjugates (ADCs), where it is attached to a monoclonal antibody via a linker for targeted delivery.
pharmaceutical intermediate for ADC manufacturingresearch compound for targeted cancer therapy studies
Portée du contenu: Les informations de cette page concernent l'identification chimique ainsi que les contextes d'approvisionnement industriel, de recherche et de production. Elles ne constituent ni une allégation thérapeutique, ni un avis médical, ni une notice d'utilisation médicamenteuse.
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CAS 139504-50-0
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Référence Sécurité
Danger
H300Fatal if swallowed
H310Fatal in contact with skin
H314Causes severe skin burns and eye damage
H340May cause genetic defects
H341Suspected of causing genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
Identifiants
Nom IUPAC
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate
InChIKey
ANZJBCHSOXCCRQ-FKUXLPTCSA-N
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)\C)OC)(NC(=O)O2)O
Synonymes (13)
- DM 1
- DM1 [Maytansinoid]
- Maytansinoid DM 1
- Mertansine
- Mertansine (DM1 Compound)
- Mertansine (DM1)
- Mertasine